OpenEvidence Raises $200M for ‘ChatGPT for Medicine’

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OpenEvidence Secures $200M in Major AI Health Bet

OpenEvidence, a three-year-old artificial intelligence startup, has raised $200 million in a new funding round that signals surging investor confidence in AI-powered clinical tools. Backed by top-tier venture firms and health tech veterans, the company is being hailed as the “ChatGPT for medicine”—but with a critical difference: every output is grounded in peer-reviewed medical literature and real-world clinical guidelines.

The investment comes as OpenEvidence’s platform sees explosive adoption among physicians, nurses, pharmacists, and hospital administrators across the U.S. and Europe. Daily active users have grown over 400% in the past 12 months alone.

What Is OpenEvidence?

Unlike general-purpose AI chatbots, OpenEvidence is purpose-built for healthcare professionals. The platform ingests and continuously updates from:

  • Over 50 million peer-reviewed journal articles
  • Clinical practice guidelines from bodies like the CDC, WHO, and NICE
  • Real-time drug databases and formulary restrictions
  • Electronic health record (EHR) integration pilots with major hospital systems

When a doctor asks, “What’s the latest first-line treatment for pediatric asthma in patients with comorbid eczema?” OpenEvidence doesn’t guess—it cites current guidelines, flags contraindications, and even suggests local formulary alternatives.

Why Clinicians Are Adopting It at Record Rates

In a field where time is life, OpenEvidence cuts through information overload. A recent internal survey found:

Metric Impact
Average time saved per query 8–12 minutes
Clinicians reporting “high trust” in outputs 78%
Reduction in diagnostic uncertainty 34% (self-reported)

“It’s like having a senior attending in your pocket,” said Dr. Lena Ruiz, an ER physician in Chicago who uses OpenEvidence during night shifts. “But one who’s read every journal published this century.”

Challenges and Ethical Guardrails

Despite enthusiasm, experts caution that AI in medicine demands rigorous oversight. OpenEvidence addresses this by:

  • Never generating “hallucinated” citations
  • Flagging low-certainty recommendations
  • Requiring user credentials (only licensed clinicians can access full features)
  • Undergoing regular audits by independent medical ethicists

The company has also opted out of direct-to-consumer use—this isn’t an app for patients to self-diagnose.

The Future of Clinical AI

With fresh capital, OpenEvidence plans to expand into:

  1. Real-time clinical decision support embedded in EHR workflows
  2. AI-assisted prior authorization automation
  3. Multilingual support for global health systems

“We’re not replacing doctors,” said CEO Arjun Mehta. “We’re giving them superpowers.”

[INTERNAL_LINK:health-tech] | [INTERNAL_LINK:ai-in-medicine]

Sources

The New York Times – OpenEvidence Raises $200 Million for a ChatGPT for Medicine

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